New paper in Biochimie

Congratulations to Dr Yu Li for her new paper in Biochimie (impact factor: 3.362), which describes her work in the production and characterisation of recombinant grape polyphenol oxidase. Thanks also to everyone who has contributed to this project, including Mark, Martin, Stuart and Paul.

New paper in Scientific Reports

Congratulations to Danilo and team for our new paper in Scientific Reports. In the paper, we describe an improved methodology for the production and purification of ribosomal proteins. Ribosomal proteins are very difficult to work with, but thanks to Danilo’s perseverance, we managed to develop a better method. I would also like to acknowledge the … Read more

New paper in Anti-Cancer Agents Med. Chem.

Congratulations Jinal for her third paper this year – “Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments” This work is led by collaborators from Novosibirsk, Russia, and in collaboration with Dr Jóhannes Reynisson & his group at the School of Chemical Sciences in Auckland.

New paper in Eur. J. Med. Chem.

Congratulations to Jinal for her second paper in two months. This paper, which was published today in the European Journal of Medicinal Chemistry (2017 impact factor: 4.816), describes a new class of TDP1 inhibitors that shows synergy with topotecan, a clinically-used topoisomerase inhibitor. This work was conducted in collaboration with Dr Jóhannes Reynisson and his … Read more

New Paper in Molecules

Congratulations to Jinal for her new paper that was published in Molecules earlier today. In this work, we used a combination of organic syntheses, biophysical measurements and molecular modellings to develop new TDP1 inhibitors. This work was conducted in collaboration with Professor Konstantin Volcho and his colleagues at the N. N. Vorozhtsov Novosibirsk Institute of … Read more

New Publication in Drug Discovery Today

Congratulations to Aimee and Mike! Their review article on MCR-1, a phosphoethanolamine transferase that causes polymyxin resistance, was published on the journal Drug Discovery Today (impact factor: 6.848). This comprehensive review covers the structure, function and mechanism and MCR-1. This project was conducted in collaboration with Associate Professor Chris Squire. You can read the review … Read more

New paper in ChemistrySelect

Congratulations to Yu Li, who is co-supervised by Professor Paul Kilmartin and Ivan, for her first-author paper in ChemistrySelect, which was published today. The paper described her work in the development of a NMR-based kinetic and inhibition assay to study polyphenol oxidases. Together with Ayesha Zafar from the group of Dr Jóhannes Reynisson, Yu applied … Read more

New paper in MedChemComm

Congratulations to Ram and Brooke! Their paper on ICL1 assay development is published in MedChemComm (impact factor: 2.608) today. Thanks also to Krunal (Reynisson Group) for virtual screening, Anne (Sperry Group) for the synthesis of methylisocitrate and Ghader for his help in ICL1 expression and purification. The paper is published in the open access format. … Read more

New paper in OBC

Congratulations to Thomas Hanauer (TU Bergakademie Freiberg; Dr Tobias Gruber Research Group, now University of Lincoln, UK), who joined our Laboratory as a visiting student in 2015, for his new publication in Organic & Biomolecular Chemistry. The paper describes his work investigating the interactions between carboxycalixarene and methylated lysines and related compounds that he conducted … Read more

Paper on HSP90

Congratulation to Mike, Nasri and Yu. Their work on the development of HSP90 inhibitors, which was conducted in collaboration with Dr Jóhannes Reynisson and his student Daniel Ayine-Tora, was accepted for publication in Bioorganic & Medicinal Chemistry Letters. Nasri started the HSP90 work during his BScH project in 2015, which Mike has carried on during … Read more

New Cover

Our review article “Protein-directed combinatorial chemistry: a guide to protein ligand and inhibitor discovery”, written by Mike and Ivan, has made to the cover of the July edition of the journal Molecules. You can read the article via the link here.