Publications

Overview



Journal articles

67
Leung, E.; Patel, J.; Hollywood, J. A.; Zafar, A.; Tomek, P.; Barker, D.; Pilkington, L. I.; van Rensburg, M.; Langley, R. J.; Helsby, N. A.; Squire, C. J.; Baguley, B. C.; Denny, W. A.; Reynisson, J.; Leung, I. K. H. Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs. Oncol. Ther. 2021, DOI: 10.1007/s40487-021-00158-0.

66
Mbenza, N. M.; Nasarudin, N.; Vadakkedath, P. G.; Patel, K.; Ismail, A. Z.; Hanif, M.; Wright, L. J.; Sarojini, V.; Hartinger, C. G.; Leung, I. K. H. Carbon Monoxide is an Inhibitor of HIF Prolyl Hydroxylase Domain 2. ChemBioChem 2021, DOI: 10.1002/cbic.202100181.

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65
Mak, O. W.; Sharma, N.; Reynisson, J.; Leung, I. K. H. Discovery of Novel Hsp90 C-Terminal Domain Inhibitors that Disrupt Co-Chaperone Binding. Bioorg. Med. Chem. Lett. 2021, 38, 127857.

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64
Sharma, N.; Langley, R. J.; Eurtivong, C.; Leung, E.; Dixon, R. J.; Paulin, E. K.; Rees, S. W. P.; Pilkington, L. I.; Barker, D.; Reynisson, J.; Leung, I. K. H. An Optimised MALDI-TOF Assay for Phosphatidylcholine-Specific Phospholipase C. Anal. Methods 2021, 13, 491–496.

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63
Kwai, B. X. C.; Collins, A. J.; Middleditch, M. J.; Sperry, J.; Bashiri, G.; Leung, I. K. H. Itaconate is a Covalent Inhibitor of the Mycobacterium tuberculosis Isocitrate Lyase. RSC Med. Chem. 2021, 12, 57–61.

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62
Correddu, D.; Sharma, N.; Kaur, S.; Varnava, K. G.; Mbenza, N. M.; Sarojini, V.; Leung, I. K. H. An Investigation into the Effect of Ribosomal Protein S15 Phosphorylation to its Intermolecular Interactions by Using Phosphomimetic Mutant. Chem. Commun. 2020, 56, 7857–7860.

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61
McLarin, M.-A.; Leung, I. K. H. Substrate Specificity of Polyphenol Oxidase. Crit. Rev. Biochem. Mol. Biol. 2020, 55, 274–308.

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60
Pilkington, L. I.; Sparrow, K.; Rees, S. W. P.; Paulin, E. K.; van Rensburg, M.; Xu, C. S.; Langley, R. J.; Leung, I. K. H.; Reynisson, J.; Leung, E.; Barker, D. Development, Synthesis and Biological Investigation of a Novel Class of Potent PC-PLC Inhibitors. Eur. J. Med. Chem. 2020, 191, 112162.

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59
Mohan, A.; Hadi, J.; Gutierrez-Maddox, N.; Li, Y.; Leung, I. K. H.; Gao, Y.; Shu, Q.; Quek, S.-Y. Sensory, Microbiological and Physicochemical Characterisation of Functional Manuka Honey Yogurts Containing Probiotic Lactobacillus reuteri DPC16. Foods 2020, 9, 106.

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58
Eurtivong, C.; Pilkington, L. I.; van Rensburg, M.; White, R. M.; Brar, H. K.; Rees, S.; Paulin, E. K.; Xu, C. S.; Sharma, N.; Leung, I. K. H.; Leung, E.; Barker, D.; Reynisson, J. Discovery of Novel Phosphatidylcholine-Specific Phospholipase C Drug-like Inhibitors as Potential Anticancer Agents. Eur. J. Med. Chem. 2020, 187, 111919.

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57
Correddu, D.; Montaño López, J. d. J.; Angermayr, S. A.; Middleditch, M. J.; Payne, L. S.; Leung, I. K. H. Effect of Consecutive Rare Codons on the Recombinant Production of Human Proteins in Escherichia coli. IUBMB Life 2020, 72, 266–274.

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56
Khomenko, T. M.; Zakharenko, A. L.; Chepanova, A. A.; Ilina, E. S.; Zakharova, O. D.; Kaledin, V. I.; Nikolin, V. P.; Popova, N. A.; Korchagina, D. V.; Reynisson, J.; Chand, R.; Ayine-Tora, D. M.; Patel, J.; Leung, I. K. H.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I. Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy. Int. J. Mol. Sci. 2020, 21, 126.

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55
Mak, O. W.; Chand, R.; Reynisson, J.; Leung, I. K. H. Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90). Int. J. Mol. Sci. 2019, 20, 5333.

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54
Filimonov, A. S.; Chepanova, A. A.; Luzina, O. A.; Zakharenko, A. L.; Zakharova, O. D.; Ilina, E. S.; Dyrkheeva, N. S.; Kuprushkin, M. S.; Kolotaev, A. V.; Khachatryan, D. S.; Patel, J.; Leung, I. K. H.; Chand, R.; Ayine‐Tora, D. M.; Reynisson, J.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I. New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors. Molecules 2019, 24, 3711.

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53
Bhusal, R. P.; Jiao, W.; Kwai, B. X. C.; Reynisson, J.; Collins, A. J.; Sperry, J.; Bashiri, G.; Leung, I. K. H. Acetyl-CoA-Mediated Activation of Mycobacterium tuberculosis Isocitrate Lyase 2. Nat. Commun. 2019, 10, 4639.

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52
Li, Y.; McLarin, M.-A.; Middleditch, M. J.; Morrow, S. J.; Kilmartin, P. A.; Leung, I. K. H. An Approach to Recombinantly Produce Mature Grape Polyphenol Oxidase. Biochimie 2019, 165, 40–47.

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51
Chepanova, A. A.; Mozhaitsev, E. S.; Munkuev, A. A.; Suslov, E. V.; Korchagina, D. V.; Zakharova, O. D.; Zakharenko, A. L.; Patel, J.; Ayine-Tora, D. M.; Reynisson, J.; Leung, I. K. H.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I. The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamides Bridges. Appl. Sci. 2019, 9, 2767.

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50
Correddu, D.; Montaño López, J. d. J.; Vadakkedath, P. G.; Lai, A.; Pernes, J. I.; Watson, P. R.; Leung, I. K. H. An Improved Method for the Heterologous Production of Soluble Human Ribosomal Proteins in Escherichia coli. Sci. Rep. 2019, 9, 8884.

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49
Correddu, D.; Leung, I. K. H. Targeting mRNA Translation in Parkinson’s Disease. Drug Discov. Today 2019, 24, 1295–1303.

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48
Mozhaitsev, E. S.; Zakharenko, A. L.; Suslov, E. V.; Korchagina, D. V.; Zakharova, O. D.; Vasil’eva, I. A.; Chepanova, A. A.; Black, E.; Patel, J.; Chand, R.; Reynisson, J.; Leung, I. K. H.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I. Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments. Anti-Cancer Agents Med. Chem. 2019, 19, 463–472.

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47
Zakharenko, A. L.; Luzina, O. A.; Sokolov, D. N.; Kaledin, V. I.; Nikolin, V. P.; Popova, N. A.; Patel, J.; Zakharova, O. D.; Chepanova, A. A.; Zafar, A.; Reynisson, J.; Leung, E.; Leung, I. K. H.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I. Novel Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Enhance the Therapeutic Impact of Topoteсan on In Vivo Tumor Models. Eur. J. Med. Chem. 2019, 161, 581–593.

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46
Son, S. J.; Huang, R.; Squire, C. J.; Leung, I. K. H. MCR-1: A Promising Target for Structure-Based Design of Inhibitors to Tackle Polymyxin Resistance. Drug Discov. Today 2019, 24, 206–216.

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45
Abboud, M. I.; Chowdhury, R.; Leung, I. K. H.; Lippl, K.; Loenarz, C.; Claridge, T. D. W.; Schofield, C. J. Studies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain. ChemBioChem 2018, 19, 2262–2267.

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44
Li-Zhulanov, N. S.; Zakharenko, A. L.; Chepanova, A. A.; Patel, J.; Zafar, A.; Volcho, K. P.; Salakhutdinov, N. F.; Reynisson, J.; Leung, I. K. H.; Lavrik, O. I. A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold. Molecules 2018, 23, 2468.

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43
Zhang, S.; De Leon Rodriguez, L. M.; Huang, R.; Leung, I. K. H.; Harris, P. W. R.; Brimble, M. A. Total Synthesis of the Proposed Structure of Talarolide A. Org. Biomol. Chem. 2018, 16, 5286–5293.

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42
McAllister, T. E.; Yeh, T.-L.; Abboud, M. I.; Leung, I. K. H.; Hookway, E. S.; King, O. N. F.; Bhushan, B.; Williams, S. T.; Hopkinson, R. J.; Muenzel, M.; Loik, N. D.; Chowdhury, R.; Oppermann, U.; Claridge, T. D. W.; Goto, Y.; Suga, H.; Schofield, C. J.; Kawamura, A. Non-Competitive Cyclic Peptides for Targeting Enzyme-Substrate Complexes. Chem. Sci. 2018, 9, 4569–4578.

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41
Abboud, M. I.; McAllister, T. E.; Leung, I. K. H.; Chowdhury, R.; Jorgensen, C.; Domene, C.; Mecinović, J.; Lippl, K.; Hancock, R. L.; Hopkinson, R. J.; Kawamura, A.; Claridge, T. D. W.; Schofield, C. J. 2-Oxoglutarate Regulates Binding of Hydroxylated Hypoxia-Inducible Factor to Prolyl Hydroxylase Domain 2. Chem. Commun. 2018, 54, 3130–3133.

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40
Zhang, S.; De Leon Rodriguez, L. M.; Leung, I. K. H.; Cook, G. M.; Harris, P. W.; Brimble, M. A. Total Synthesis and Conformational Study of Callyaerin A: Anti-Tubercular Cyclic Peptide Bearing a Rare Rigidifying (Z)-2,3-Diaminoacrylamide Moiety. Angew. Chem. Int. Ed. 2018, 57, 3631–3635; Angew. Chem. 2018, 130, 3693–3697.

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39
Mbenza, N. M.; Vadakkedath, P. G.; McGillivray, D. J.; Leung, I. K. H. NMR Studies of the Non-Haem Fe(II) and 2-Oxoglutarate-Dependent Oxygenases. J. Inorg. Biochem. 2017, 177, 384–394.

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38
Li, Y.; Zafar, A.; Kilmartin, P. A.; Reynisson, J.; Leung, I. K. H. Development and Application of an NMR-Based Assay for Polyphenol Oxidases. ChemistrySelect 2017, 2, 10435–10441.

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37
Bhusal, R. P.; Patel, K.; Kwai, B. X. C.; Swartjes, A.; Bashiri, G.; Reynisson, J.; Sperry, J.; Leung, I. K. H. Development of NMR and Thermal Shift Assays for the Evaluation of Mycobacterium tuberculosis Isocitrate Lyase Inhibitors. Med. Chem. Commun. 2017, 8, 2155–2163.

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36
Yeh, T.-L.; Leissing, T. M.; Abboud, M. I.; Thinnes, C. C.; Atasoylu, O.; Holt-Martyn, J. P.; Zhang, D.; Tumber, A.; Lippl, K.; Lohans, C. T.; Leung, I. K. H.; Morcrette, H.; Clifton, I. J.; Claridge, T. D. W.; Kawamura, A.; Flashman, E.; Lu, X.; Ratcliffe, P. J.; Chowdhury, R.; Pugh, C. W.; Schofield, C. J. Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase Inhibitors in Clinical Trials. Chem. Sci. 2017, 8, 7651–7668.

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35
Bhusal, R. P.; Bashiri, G.; Kwai, B. X. C.; Sperry, J.; Leung, I. K. H. Targeting Isocitrate Lyase for the Treatment of Latent Tuberculosis. Drug Discov. Today 2017, 22, 1008–1016.

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34
Santoso, B.; Yanaranop, P.; Kang, H.; Leung, I. K. H.; Jin, J. A Critical Update on the Synthesis of Carboxylated Polymers of Intrinsic Microporosity (C-PIMs). Macromolecules 2017, 50, 3043–3050.

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33
Kong, C. H. Z.; Leung, I. K. H.; Sarojini, V. Synthetic Insect Antifreeze Peptides Modify Ice Crystal Growth Habit. CrystEngComm 2017, 19, 2163–2167.

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32
Huang, R.; Bonnichon, A.; Claridge, T. D. W.; Leung, I. K. H. Protein-Ligand Binding Affinity Determination by the WaterLOGSY Method: An Optimised Approach Considering Ligand Rebinding. Sci. Rep. 2017, 7, 43727.

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31
Hanauer, T.; Hopkinson, R. J.; Patel, K.; Li, Y.; Correddu, D.; Kawamura, A.; Sarojini, V.; Leung, I. K. H.; Gruber, T. Selective Recognition of the Di/Trimethylammonium Motif by an Artificial Carboxycalixarene Receptor. Org. Biomol. Chem. 2017, 15, 1100–1105.

31

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30
Harris, P. W. R.; Cook, G. M.; Leung, I. K. H.; Brimble, M. A. An Efficient Chemical Synthesis of Lassomycin Enabled by an On-Resin Lactamisation/Off-Resin Methanolysis Strategy and Preparation of Chemical Variants. Aust. J. Chem. 2017, 70, 172–183.

26

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29
Young, P. G.; Yosaatmadja, Y.; Harris, P. W. R.; Leung, I. K. H.; Baker, E. N.; Squire, C. J. Harnessing Ester Bond Chemistry for Protein Ligation. Chem. Commun. 2017, 53, 1502–1505.

30

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28
Huang, R.; Ayine-Tora, D. M.; Muhammad Rosdi, M. N.; Li, Y.; Reynisson, J.; Leung, I. K. H. Virtual Screening and Biophysical Studies Lead to HSP90 Inhibitors. Bioorg. Med. Chem. Lett. 2017, 27, 277–281.

29

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27
Zhang, S.; De Leon Rodriguez, L. M.; Lacey, E.; Piggott, A. M.; Leung, I. K. H.; Brimble, M. A. Cyclisation of Linear Tetrapeptides Containing N-Methylated Amino Acids Using 2-Propanephosphonic Acid Anhydride. Eur. J. Org. Chem. 2017, 2017, 149–158.

28

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26
Lindsay, A. C.; Leung, I. K. H.; Sperry, J. Synthesis of the Azepinobisindole Alkaloid Iheyamine A Enabled by a Cross-Mannich Reaction. Org. Lett. 2016, 18, 5404–5407.

27

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25
Chowdhury, R.; Leung, I. K. H.; Tian, Y.-M.; Abboud, M. I.; Ge, W.; Domene, C.; Cantrelle, F.-X.; Landrieu, I.; Hardy, A. P.; Pugh, C. W.; Ratcliffe, P. J.; Claridge, T. D. W.; Schofield, C. J. Structural Basis for Oxygen Degradation Domain Selectivity of the HIF Prolyl Hydroxylases. Nat. Commun. 2016, 7, 12673.

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24
Huang, R.; Leung, I. K. H. Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery. Molecules 2016, 21, 910.

molecules

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23
Khan, A.; Leśniak, R. K.; Brem, J.; Rydzik, A. M.; Choi, H.; Leung, I. K. H.; McDonough, M. A.; Schofield, C. J.; Claridge, T. D. W. Development and Application of Ligand-Based NMR Screening Assays for γ-Butyrobetaine Hydroxylase. Med. Chem. Commun. 2016, 7, 873–880.

MedChemComm23

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22
Hopkinson, R. J.; Leung, I. K. H.; Smart, T. J.; Rose, N. R.; Henry, L.; Claridge, T. D. W.; Schofield, C. J. Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificansPLoS ONE 2015, 10, e0145085.

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21
Chan, M. C.; Atasoylu, O.; Hodson, E.; Tumber, A.; Leung, I. K. H.; Chowdhury, R.; Gómez-Pérez, V.; Demetriades, M.; Rydzik, A. M.; Holt-Martyn, J.; Tian, Y.-M.; Bishop, T.; Claridge, T. D. W.; Kawamura, A.; Pugh, C. W.; Ratcliffe, P. J.; Schofield, C. J. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases With Activity in the Murine Brain. PLoS ONE 2015, 10, e0132004.

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20
Tarhonskaya, H.; Chowdhury, R.; Leung, I. K. H.; Loik, N. D.; McCullagh, J. S. O.; Claridge, T. D. W.; Schofield, C. J.; Flashman, E. Investigating the Contribution of the Active Site Environment to the Slow Reaction of Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 With Oxygen. Biochem. J. 2014, 463, 363–372.

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19
Rydzik, A. M.; Leung, I. K. H.; Kochan, G. T.; McDonough, M. A.; Claridge, T. D. W.; Schofield, C. J. Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-Piperidine-4-Carboxylic Acids. Angew. Chem. Int. Ed. 2014, 53, 10925–10927; Angew. Chem. 2014, 126, 11105–11107.

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18
Scotti, J. S.; Leung, I. K. H.; Ge, W.; Bentley, M. A.; Paps, J.; Kramer, H. B.; Lee, J.; Aik, W.; Choi, H.; Paulsen, S. M.; Bowman, L. A. H.; Loik, N. D.; Horita, S.; Ho, C.-h.; Kershaw, N. J.; Tang, C. M.; Claridge, T. D. W.; Preston, G. M.; McDonough, M. A.; Schofield, C. J. Human Oxygen Sensing May Have Origins in Prokaryotic Elongation Factor Tu Prolyl-Hydroxylation. Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 13331–13336.

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17
Rydzik, A. M.; Leung, I. K. H.; Kochan, G. T.; Loik, N. D.; Henry, L.; McDonough, M. A.; Claridge, T. D. W.; Schofield, C. J. Comparison of the Substrate Selectivity and Biochemical Properties of Human and Bacterial γ-Butyrobetaine Hydroxylase. Org. Biomol. Chem. 2014, 12, 6354–6358.

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16
Tarhonskaya, H.; Szöllössi, A.; Leung, I. K. H.; Bush, J. T.; Henry, L.; Chowdhury, R.; Iqbal, A.; Claridge, T. D. W.; Schofield, C. J.; Flashman, E. Studies on Deacetoxycephalosporin C Synthase Support a Consensus Mechanism for 2-Oxoglutarate Dependent Oxygenases. Biochemistry 2014, 53, 2483–2493.

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15
Lingard, H.; Han, J. T.; Thompson, A. L.; Leung, I. K. H.; Scott, R. T. W.; Thompson, S.; Hamilton, A. D. Diphenylacetylene-Linked Peptide Strands Induce Bidirectional β-Sheet Formation. Angew. Chem. Int. Ed. 2014, 53, 3650–3653; Angew. Chem. 2014, 126, 3724–3727.

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14
Tarhonskaya, H.; Rydzik, A. M.; Leung, I. K. H.; Loik, N. D.; Chan, M. C.; Kawamura, A.; McCullagh, J. S. O.; Claridge, T. D. W.; Flashman, E.; Schofield, C. J. Non-Enzymatic Chemistry Enables 2-Hydroxyglutarate-Mediated Activation of 2-Oxoglutarate Oxygenases. Nat. Commun. 2014, 5, 3423.

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13
Rydzik, A. M.; Leung, I. K. H.; Thalhammer, A.; Kochan, G. T.; Claridge, T. D. W.; Schofield, C. J. Fluoromethylated Derivatives of Carnitine Biosynthesis Intermediates – Synthesis and Applications. Chem. Commun. 2014, 50, 1175−1177.

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12
Bush, J. T.; Walport, L. J.; McGouran, J. F.; Leung, I. K. H.; Berridge, G.; van Berkel, S. S.; Basak, A.; Kessler, B. M.; Schofield, C. J. The Ugi Four-Component Reaction Enables Expedient Synthesis and Comparison of Photoaffinity Probes. Chem. Sci. 2013, 4, 4115−4120.

11

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11
van Berkel, S. S.; Nettleship, J. E.; Leung, I. K. H.; Brem, J.; Choi, H.; Stuart, D. I.; Claridge, T. D. W.; McDonough, M. A.; Owens, R. J.; Ren, J.; Schofield, C. J. Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3. ACS Chem. Biol. 2013, 8, 2112–2116.

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10
Leung, I. K. H.; Demetriades, M.; Hardy, A. P.; Lejeune, C.; Smart, T. J.; Szöllössi, A.; Kawamura, A.; Schofield, C. J.; Claridge, T. D. W. Reporter Ligand NMR Screening Method for 2-Oxoglutarate Oxygenase Inhibitors. J. Med. Chem. 2013, 56, 547–555.

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9
Henry, L.; Leung, I. K. H.; Claridge, T. D. W.; Schofield, C. J. γ-Butyrobetaine Hydroxylase Catalyses a Stevens Type Rearrangement. Bioorg. Med. Chem. Lett. 2012, 22, 4975–4978.

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8
Rose, N. R.; Woon, E. C.; Tumber, A.; Walport, L. J.; Chowdhury, R.; Li, X. S.; King, O. N. F.; Lejeune, C.; Ng, S. S.; Krojer, T.; Chan, M. C.; Rydzik, A. M.; Hopkinson, R. J.; Che, K. H.; Daniel, M.; Strain-Damerell, C.; Gileadi, C.; Kochan, G.; Leung, I. K. H.; Dunford, J.; Yeoh, K. K.; Ratcliffe, P. J.; Burgess-Brown, N.; von Delft, F.; Muller, S.; Marsden, B.; Brennan, P. E.; McDonough, M. A.; Oppermann, U.; Klose, R. J.; Schofield, C. J.; Kawamura, A. The Plant Growth Regulator Daminozide Is a Selective Inhibitor of the Human KDM2/7 Histone Demethylases. J. Med. Chem. 2012, 55, 6639–6643.

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7
Rydzik, A. M.; Leung, I. K. H.; Kochan, G. T.; Thalhammer, A.; Oppermann, U.; Claridge, T. D. W.; Schofield, C. J. Development and Application of a Fluoride-Detection-Based Fluorescence Assay for γ-Butyrobetaine Hydroxylase. ChemBioChem 2012, 13, 1559–1563.

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6
Demetriades, M.; Leung, I. K. H.; Chowdhury, R.; Chan, M. C.; McDonough, M. A.; Yeoh, K. K.; Tian, Y.-M.; Claridge, T. D. W.; Ratcliffe, P. J.; Woon, E. C. Y.; Schofield, C. J. Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors. Angew. Chem. Int. Ed. 2012, 51, 6672–6675; Angew. Chem. 2012, 124, 6776–6779.

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5
Rotili, D.; Altun, M.; Kawamura, A.; Wolf, A.; Fischer, R.; Leung, I. K. H.; Mackeen, M. M.; Tian, Y.-M.; Ratcliffe, P. J.; Mai, A.; Kessler, B. M.; Schofield, C. J. A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases. Chem. Biol. 2011, 18, 642–654.

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4
Leung, I. K. H.; Brown Jr, T.; Schofield, C. J.; Claridge, T. D. W. An Approach to Enzyme Inhibition Employing Reversible Boronate Ester Formation. Med. Chem. Commun. 2011, 2, 390–395.

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3
Chowdhury, R.; Yeoh, K. K.; Tian, Y.-M.; Hillringhaus, L.; Bagg, E. A.; Rose, N. R.; Leung, I. K. H.; Li, X. S.; Woon, E. C. Y.; Yang, M.; McDonough, M. A.; King, O. N.; Clifton, I. J.; Klose, R. J.; Claridge, T. D. W.; Ratcliffe, P. J.; Schofield, C. J. ; Kawamura, A. The Oncometabolite 2-Hydroxyglutarate Inhibits Histone Lysine Demethylases. EMBO Rep. 2011, 12, 463–469.

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2
Leung, I. K. H.; Krojer, T. J.; Kochan, G. T.; Henry, L.; von Delft, F.; Claridge, T. D. W.; Oppermann, U.; McDonough, M. A.; Schofield, C. J. Structural and Mechanistic Studies on γ-Butyrobetaine Hydroxylase. Chem. Biol. 2010, 17, 1316–1324.

cited by count

1
Leung, I. K. H.; Flashman, E.; Yeoh, K. K.; Schofield, C. J.; Claridge, T. D. W. Using NMR Solvent Water Relaxation to Investigate Metalloenzyme–Ligand Binding Interactions. J. Med. Chem. 2010, 53, 867–875.

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Book chapters

2
Huang, R.; Leung, I. K. H. Protein–Small Molecule Interactions by WaterLOGSY. In Methods in Enzymology; Wand, A. J., Ed.; Biological NMR Part B; Academic Press: Cambridge, MA, 2019; Vol. 615, Chapter 14, pp 477–500.

cited by count

1
Xiang, L.-W.; Melton, L. D.; Leung, I. K. H. Interactions of β-Lactoglobulin With Small Molecules. In Encyclopedia of Food Chemistry; Melton, L., Shahidi, F., Varelis, P., Eds.; Elsevier: Amsterdam, 2019; Vol. 2, pp 560–565.