Current Research

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Our research focusses on the application of biophysical techniques to a variety of problems in chemistry and biology. In particular, we are interested in understanding the chemical, structural and mechanistic basis of proteins and enzymes, and the links to their biological functions.

The biophysical techniques that our research group typically employ include:

  • Solution-state nuclear magnetic resonance (NMR) spectroscopy
  • Protein X-ray crystallography
  • Thermal shift assaying
  • Non-denaturing native mass spectrometry
  • Isothermal titration calorimetry

There are three major research themes in our laboratory:

  • Inhibitor discovery
    • Enzymes that are related to human health and disease
    • Plant enzymes that are important for agricultural applications
  • Structural and mechanistic enzymology
    • Effect of posttranslational modification on ribosomal proteins
    • Catalytic mechanism of plant oxidases
  • Method development
    • NMR method development to study protein-ligand interactions
    • Methods to detect posttranslational modifications